Preheat the oven to 375 degrees.
Brown the ground beef in a large skillet with the onion and garlic. When the meat is cooked through, stir in the sauce and remove from heat.
In a large bowl, stir the ricotta cheese, cottage cheese, parmesan cheese, Italian seasoning, salt, and pepper.
Spread a layer of sauce over the bottom of a 9x13 baking dish. Top the sauce with a layer of lasagna noodles.
Spread a layer of ricotta cheese mixture over the noodles, topped by a layer of sauce and a layer of shredded mozzarella cheese.
Continue layering the pasta, ricotta cheese, sauce, and shredded cheese until all the pasta has been used. Top the lasagna with a layer of sauce and remaining cheese.
Cover the pan with foil and bake in the oven for 45 minutes, then remove the covering and cook for an additional 10 to 15 minutes, until the cheese is beginning to brown.
Allow the lasagna to rest for 10 minutes before slicing and serving.